Bipolar polygenic loading and bipolar spectrum features in major depressive disorder
نویسندگان
چکیده
منابع مشابه
Comparison of depressive episodes in bipolar disorder and in major depressive disorder within bipolar disorder pedigrees.
BACKGROUND Although genetic epidemiological studies have confirmed increased rates of major depressive disorder among the relatives of people with bipolar affective disorder, no report has compared the clinical characteristics of depression between these two groups. AIMS To compare clinical features of depressive episodes across participants with major depressive disorder and bipolar disorder...
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CONTEXT It has been suggested that patients with major depressive disorder (MDD) who display pretreatment features suggestive of bipolar disorder or bipolar spectrum features might have poorer treatment outcomes. OBJECTIVE To assess the association between bipolar spectrum features and antidepressant treatment outcome in MDD. DESIGN Open treatment followed by sequential randomized controlle...
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BACKGROUND Mitochondria provide most of the energy for brain cells by the process of oxidative phosphorylation. Mitochondrial abnormalities and deficiencies in oxidative phosphorylation have been reported in individuals with schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) in transcriptomic, proteomic, and metabolomic studies. Several mutations in mitochondrial DNA...
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The lifetime prevalence rates of unipolar depression (UPD) in males and females of first-world countries are approximately 15 and 25 percent, respectively. The figures appear to be equally disheartening in developing countries: The 12-month prevalence of major depressive disorder in South Africa is roughly 5 percent. It is therefore not surprising that 25 percent of all visits to health care pr...
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Subcortical gray matter regions have been implicated in mood disorders, including Major Depressive Disorder (MDD) and Bipolar Disorder (BD). It is unclear, however, whether or how these regions differ among mood disorders and whether such abnormalities are state- or trait-like. In this study, we examined differences in subcortical gray matter volumes among euthymic BD, MDD, remitted MDD (RMD), ...
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ژورنال
عنوان ژورنال: Bipolar Disorders
سال: 2014
ISSN: 1398-5647
DOI: 10.1111/bdi.12201